I upgraded to IE8, and my site works fine - as do most others that I've viewed.
I have seen some sites that had some odd behavior; it depends on your customizations. IE8 does have a compatibility button that can be used if you see behavior differences with your site - but I'd recommend fixing any problems that crop up.
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IE6, IE7, IE8 on Windows (XP, Vista)
FF3 and above (Mac and Win)
Safari 3 and above (Mac and Win)
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I have seen some sites that had some odd behavior; it depends on your customizations. IE8 does have a compatibility button that can be used if you see behavior differences with your site - but I'd recommend fixing any problems that crop up.
--- Denise
Musings & ramblings at https://denisegoldberg.blogspot.com